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Drug Pathways & Tech

SmithRx: The First PBM to Offer a Humira Biosimilar

SmithRx: The First PBM to Offer a Humira Biosimilar

Alan Pannier

Since launching in July 2023, SmithRx has continued expanding access to lower-cost biosimilars like Yusimry as part of its transparent PBM model.Teaming up with Mark Cuban Cost Plus Drug Company, SmithRx will start offering members Yusimry beginning in July 2023

SmithRx announced today that we will offer YUSIMRY, a biosimilar of Humira, to our members for more than 90 percent less than the list price of Humira. Working with Mark Cuban Cost Plus Drug Company, PBC, SmithRx will cover YUSIMRY when it is launched in early July 2023. YUSIMRY will be available through the Cost Plus Drugs online mail-order pharmacy for $569.27 plus dispensing and shipping fees, compared to the current price of Humira of $6,922 per carton. Unique to this collaboration, SmithRx members will be able to apply their insurance benefits to further reduce their out-of-pocket costs for YUSIMRY.

Unlike traditional pharmacy benefit managers (PBMs), SmithRx prioritizes transparency and up-front cost savings. Humira is often an employer’s top drug expense so offering a low-cost alternative will have a significant impact. We’re excited to work with Cost Plus Drugs to bring this biosimilar to our members – and significantly reduce costs for them and their employers.

Jake Frenz, CEO and founder of SmithRx

Humira, the top-selling pharmaceutical in the world, is also one of the most expensive medications in America and is used to treat a range of auto-immune conditions including rheumatoid arthritis, Crohn’s disease, ulcerative colitis, and plaque psoriasis. Humira is used by more than 300,000 patients in the U.S., and biosimilar versions of it have only just come to market.

This will be the first time that a Humira biosimilar is available to patients through a PBM at low and transparent price. When a previous biosimilar was released earlier this year, legacy PBMs made it available only through the standard model of high list prices coupled with opaque rebates.

Working with SmithRx, a transparent PBM, has been a great experience for Mark Cuban Cost Plus Drug Company. Their commitment to transparency and efficiency aligns perfectly with our mission to provide affordable and accessible medications to all. Together, we are forging a new path in the pharmaceutical industry, ensuring that patients receive the best care at the most reasonable costs.

Alex Oshmyansky, CEO of Mark Cuban Cost Plus Drug Company

On June 1, 2023, Mark Cuban Cost Plus Drug Company and Coherus Biosciences announced plans to offer Cost Plus Drug Company customers YUSIMRY (adalimumab-aqvh), a biosimilar of HUMIRA (adalimumab injection), in July 2023.

To learn more about how to save on YUSIMRY and other prescription medicines, contact SmithRx today.

YUSIMRY
Alan Pannier

Chief Strategy Officer, SmithRx

Alan oversees the company's pharmacy initiatives, including manufacturer relations, network management, and clinical solutions. His background includes clinical leadership roles at Magellan Health and Veridicus Health, as well as hands-on experience as a practicing pharmacist. Alan's academic credentials include an MBA and PharmD from Idaho State University, a Bachelor's in Chemistry and Business from Westminster College, and specialized training in managed care pharmacy. His comprehensive understanding of the industry drives SmithRx's innovative approach to pharmacy benefits management.

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Drug Pathways & Tech

Aligned by Design: What Purpose-Built AI Looks Like in Modern Pharmacy Benefits

Not all AI is built the same. SmithRx VP of Engineering Gaston Concilio breaks down what purpose-built AI actually looks like in pharmacy benefits.

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Abstract overhead view of interconnected circular nodes on a blue background, with one orange node at the center of a hub-and-spoke pattern

Drug Pathways & Tech

Aligned by Design: What Purpose-Built AI Looks Like in Modern Pharmacy Benefits

Not all AI is built the same. SmithRx VP of Engineering Gaston Concilio breaks down what purpose-built AI actually looks like in pharmacy benefits.

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Drug Pathways & Tech

How Technology is Bringing ‘Humanity’ Back to Pharmacy Benefits

SmithRx CTO Bhavini Soneji explores how AI and modern platform architecture are redefining what makes a PBM. Discover how a "human-first" tech strategy delivers exceptional savings and scalability while deepening empathy in healthcare.

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Drug Pathways & Tech

How Technology is Bringing ‘Humanity’ Back to Pharmacy Benefits

SmithRx CTO Bhavini Soneji explores how AI and modern platform architecture are redefining what makes a PBM. Discover how a "human-first" tech strategy delivers exceptional savings and scalability while deepening empathy in healthcare.

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Drug Pathways & Tech

The Engine of Healthcare: How AI Is Powering Modern PBMs

AI won’t replace humans, but it will give them superpowers. Learn how SmithRx is deconstructing the PBM "black box" with modern tech to deliver lower net costs in our latest Full Disclosure episode.

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Drug Pathways & Tech

The Engine of Healthcare: How AI Is Powering Modern PBMs

AI won’t replace humans, but it will give them superpowers. Learn how SmithRx is deconstructing the PBM "black box" with modern tech to deliver lower net costs in our latest Full Disclosure episode.

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SmithRx is on a mission to reduce the complexity and costs of pharmacy benefits with radical transparency and cutting-edge technology.

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© 2026 Smith Health, Inc

SmithRx is on a mission to reduce the complexity and costs of pharmacy benefits with radical transparency and cutting-edge technology.

Pharmacy and Provider Line
Member Help

M-F 8am - 9pm ET; Saturday 9am - 7pm ET

© 2026 Smith Health, Inc

SmithRx is on a mission to reduce the complexity and costs of pharmacy benefits with radical transparency and cutting-edge technology.

Pharmacy and Provider Line
Member Help

M-F 8am - 9pm ET; Saturday 9am - 7pm ET

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